Retinal toxicity of intravitreal tenecteplase in the rabbit
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چکیده
منابع مشابه
Intravitreal tenecteplase (metalyse) for acute management of retinal vein occlusions.
PURPOSE To determine the ability of an intravitreal injection of tenecteplase (TNK) to penetrate an intraretinal venous thrombus and its effectiveness in thrombolysis in a porcine model of branch retinal vein occlusion (BRVO). METHODS Six pigs (group 1) were anesthetized, and a BRVO was induced photothrombotically in the left eye; immediately afterward, fluorescence-conjugated TNK (100 μg) wa...
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PURPOSE To evaluate the retinal toxicity of intravitreal bevacizumab in an animal model. DESIGN Animal study. METHODS Bevacizumab was injected into the vitreous of one eye of each of eight Dutch-belted rabbits; the other eye served as a control. Four rabbits received a dose of 1.25 mg/0.05 ml of bevacizumab intravitreally into one eye, and the other four rabbits were injected with 2.5 mg/0....
متن کاملLong-term retinal toxicity of intravitreal commercially available preserved triamcinolone acetonide (Kenalog) in rabbit eyes.
PURPOSE To investigate whether intravitreal Kenalog (IVTK; Bristol Meyers Squibb Company, Princeton, NJ) produces histologic or electroretinographic changes in the rabbit retina up to 3 months after injection. METHODS Ten Dutch-belted rabbits were injected with 4 mg/0.1 mL Kenalog in one eye and 0.1 mL physiologic salt solution (PSS) in the fellow eye. Simultaneous bilateral dark-adapted elec...
متن کاملTesting intravitreal toxicity of rapamycin in rabbit eyes.
PURPOSE To evaluate retinal toxicity of varying doses of rapamycin when injected intravitreally in rabbits. Rapamycin is a potent immunosuppressive agent with significant antitumor and antiangiogenic properties, clinically approved for prevention of organ transplant rejection. METHODS Twelve New Zealand albino rabbits were divided into four groups. Four different doses of rapamycin were prepa...
متن کاملRetinal toxicity of intravitreal kenalog in albino rabbits.
PURPOSE To evaluate possible toxicity of intravitreal Kenalog (commercial triamcinolone acetonide) to the retina of albino rabbits. METHODS Forty-three albino rabbits were injected intravitreally with 0.1 mL of experimental solution to the right eye and 0.1 mL of saline to the left eye (control). Rabbits in Group A (n=28) were injected with 4 mg/0.1 mL of Kenalog suspension; rabbits in Group ...
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ژورنال
عنوان ژورنال: British Journal of Ophthalmology
سال: 2004
ISSN: 0007-1161
DOI: 10.1136/bjo.2003.027466